Basic Information
VIS ID
TVIS44011419
Fusion event
HTLV-1-COL21A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
56214488/56349690 (Hg38)
End
56214488/56349690 (Hg38)
Orient
+
Location type
Intronic
Target gene
COL21A1
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/3072619; hsa-mir-10524/Downstream/1040442;
Nearest TSS
ENST00000381078/Upstream/101944; ENST00000426453/Downstream/44404;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/102044, chr6-CpG: 19/Downstream/82680
Nearby gene
COL21A1(-102110) ;
Upstream sequence
AGGACACTGATTTTTAATTTTTATTCTTAGAAATGTAAGAAGAGGCACAGCAATGAGTCAGAAGTGGTATAAAATGAACATGCCTGTCTTTTAAACTAAC
Downstream sequence
CCATCAAAATCATTTCTATTTCTTCTTTTACATTATTGCTTATACTTGTATTTAGGTTGCCTTACCTTCTGTTTTGTCATTTTAATGAAAGACCATTTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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