Basic Information
VIS ID
TVIS44011446
Fusion event
HTLV-1-TAB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
149640843/149319707 (Hg38)
End
149640843/149319707 (Hg38)
Orient
-
Location type
Intronic
Target gene
TAB2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-let-7b-5p ; hsa-mir-23b-3p ; hsa-mir-181a-5p ; hsa-mir-98-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-let-7f-5p ; hsa-let-7a-5p ; hsa-mir-142-3p ; hsa-mir-1273e ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-4708-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-583 ; hsa-mir-4311 ; hsa-mir-1276 ; hsa-mir-450a-1-3p ; hsa-mir-6734-5p ; hsa-mir-222-5p ; hsa-mir-6073 ; hsa-mir-5681b ; hsa-mir-4471 ; hsa-mir-8059 ; hsa-mir-4668-5p ; hsa-mir-1292-5p ; hsa-mir-3148 ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-936 ; hsa-mir-4678 ; hsa-mir-6783-5p ; hsa-mir-548m ; hsa-mir-199b-3p ; hsa-mir-3129-5p ; hsa-mir-199a-3p ; hsa-mir-651-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-342-3p
Nearest miRNA
hsa-mir-10398/Upstream/8635824; hsa-mir-1202/Downstream/1782968;
Nearest TSS
ENST00000381078/Upstream/1125; ENST00000606797/Downstream/1345;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1325, chr6-CpG: 124/Downstream/130993
Upstream sequence
TGATTCAGAACTTCTGTTTGGGTTTTTCCCCCATAGGTCTAATCAGTTTCTAATAGAGGGTGCTTAAGTTTTAAATCTTTCAAGAATCAAACTGAAAGTT
Downstream sequence
GAATACGTCAATTATAGATGAATAAGTTATCCCCTGAATATACTCCATTATTTCTTTTTTCTTTTGTGTGCATCGAGTTACTTTTCCTGAGTTTAAAAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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