Basic Information
VIS ID
TVIS44011454
Fusion event
HTLV-1-THSD7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
11749149/11709522 (Hg38)
End
11749149/11709522 (Hg38)
Orient
-
Location type
Intronic
Target gene
THSD7A
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-448 ; hsa-mir-6867-5p ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-5011-5p ; hsa-mir-586 ; hsa-mir-1277-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-3119 ; hsa-mir-3158-3p ; hsa-mir-532-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-584-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-3692-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-153-5p ; hsa-mir-210-3p
Nearest miRNA
hsa-mir-339/Upstream/4642477; hsa-mir-10399/Downstream/6417698;
Nearest TSS
ENST00000635602/Upstream/166463; ENST00000442107/Downstream/41831;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/735261, chr7-CpG: 25/Downstream/122259
Upstream sequence
CCAGTCTCATAATTTGGCCTGGTAAATGAGTTATGGTGAGTTGAATCACTTATGAATCAGGTTTGCTTCTGTGGCCATAACTCATGGAGATAATGGAAGG
Downstream sequence
AACCAGGAATCCCTTCTCTACCCATCTCCAACTGCTGTCTCTTTTGGTGTATAGTTCAGTCAATACCTGATACACTATTTTAAAAAATACAGTAAGGCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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