Basic Information
VIS ID
TVIS44011460
Fusion event
HTLV-1-TAX1BP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
27782556/27742937 (Hg38)
End
27782556/27742937 (Hg38)
Orient
-
Location type
Intronic
Target gene
TAX1BP1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-500a-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-143-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-545-5p ; hsa-mir-2681-5p ; hsa-mir-4422 ; hsa-mir-6801-5p ; hsa-mir-7844-5p ; hsa-mir-6797-3p ; hsa-mir-6076
Nearest miRNA
hsa-mir-1183/Upstream/573374; hsa-mir-10399/Downstream/1937797;
Nearest TSS
ENST00000635602/Upstream/2542; ENST00000494033/Downstream/26741;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1955, chr7-CpG: 144/Downstream/436474
Upstream sequence
ATACCTTTTCCATAACAAAAGTAAAATTTTGGAATTCAAAGTTTCAACCTTTTTAATAATGTTAAAATAATCATGAAAGATCCTAATGATGCTCCTTGTA
Downstream sequence
TACTTCTTTTGGGGACTTTGTTGTATTCTTTTGGAATGGATATGTTAAATCTGGGCTTTATGCATTTCTGTCTTTTTAAAGCTTATTTTGTCCCAAATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate