Basic Information
VIS ID
TVIS44011474
Fusion event
HTLV-1-AUTS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
70032187/70567201 (Hg38)
End
70032187/70567201 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3452804; hsa-mir-10399/Downstream/740471;
Nearest TSS
ENST00000635602/Upstream/250285; ENST00000489774/Downstream/28884;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/967150, chr7-CpG: 64/Downstream/28647
Upstream sequence
ATACTTGCCTAACTGGGGGTTTAAGGTATTGCTAGAAGCAAAATATCAGTGTGTTCATGTCTCGATCCAACTGGCCAATGAAACCCTTTATTAGGAAAAC
Downstream sequence
CTTTGCACCAGAGAAATGTCTCCAGTGACCTGAAATGGGCACACCTCATGAATGTTGAATGTTCTTCAAACTCTATTTCTTCATTCTTGACTTTTTTCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate