Basic Information
VIS ID
TVIS44011477
Fusion event
HTLV-1-chr7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
90187707/90558393 (Hg38)
End
90187707/90558393 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/14643124; hsa-mir-10399/Downstream/1645622;
Nearest TSS
ENST00000635602/Upstream/64223; ENST00000496279/Downstream/5381;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/211680, chr7-CpG: 141/Downstream/37375
Nearby gene
CDK14(+37969) ;
Nearest cancer related gene
CDK14(OG, +37969) ;
Upstream sequence
ATCCCAACTAGGAGGGCTGAGGTGAGGCAAGTCAAGGGCATGGTGGAGTGATGGGGTAGGGAAGGGGGATCAGGGATGGGGACAGATAGGACAACCACAG
Downstream sequence
GGCTTTAACCATGTGTGCCAAGACAAGTGACCAGGAATCACTTTCCAGACCTTCAAAGAGTGCATGCAGTGAAGATGGGCCAACAAGCCTCCTCACCTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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