Basic Information
VIS ID
TVIS44011478
Fusion event
HTLV-1-ANKIB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
91922151/92292837 (Hg38)
End
91922151/92292837 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7E
Target gene
ANKIB1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-3185 ; hsa-mir-5582-3p
Nearest miRNA
hsa-mir-10525/Upstream/88739; hsa-mir-10399/Downstream/1189923;
Nearest TSS
ENST00000635602/Upstream/46603; ENST00000442183/Downstream/1625;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/46300, chr7-CpG: 44/Downstream/154548
Upstream sequence
CTATGTCATATGATCCAATTAATATATACATGTTTATGTTGTGTATATGCATACATATTTTATACACACAAACACACACATACACCTTTAAATAGGGTGG
Downstream sequence
TTATGTATCAAAATGCTACCAGTGGTTTTCTTGCAGTAAACCGTGAGGTAAACCATGAGCTTTTAAATTCTTTCTCTTTGTTCATATATTCAAAAAGCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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