Basic Information
VIS ID
TVIS44011508
Fusion event
HTLV-1-ZMAT4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
40579926/40722407 (Hg38)
End
40579926/40722407 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZMAT4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-7977 ; hsa-mir-6131 ; hsa-mir-1207-3p ; hsa-mir-6768-5p ; hsa-mir-2909 ; hsa-mir-1296-5p ; hsa-mir-383-3p ; hsa-mir-4761-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-8485 ; hsa-mir-4436b-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-335-3p ; hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-6503-5p ; hsa-mir-4527 ; hsa-mir-9-5p ; hsa-mir-302a-5p ; hsa-mir-3121-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-501-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-124-1/Upstream/10765059; hsa-mir-10400/Downstream/548641;
Nearest TSS
ENST00000518652/Upstream/25070; ENST00000521725/Downstream/64375;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1199393, chr8-CpG: 20/Downstream/175238
Upstream sequence
ACACTGAGGGTGGAGGTTTCCTACACCTTATATAGCTTTGTCTTAAAGCCAGGCCATGCGACTGTAATTTAGAGCTATTAGCCAGAAGCATCTTAGTAGG
Downstream sequence
GAGGGAATTTGTATTTATAACCAGATAAGTACTGTATACAATTGGATCACACACATCTTAAAGCCACTTCCCCAGCTTTATTATGCTTGTAATGATTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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