Basic Information
VIS ID
TVIS44011517
Fusion event
HTLV-1-CA8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
61190474/60277915 (Hg38)
End
61190474/60277915 (Hg38)
Orient
-
Location type
Intronic
Target gene
CA8
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4752 ; hsa-mir-6844 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-4524b-5p ; hsa-mir-8056 ; hsa-mir-4524a-5p ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-9-5p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-135a-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-296-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-8066 ; hsa-mir-1277-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-497-5p ; hsa-mir-16-5p ; hsa-mir-6838-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-3611 ; hsa-mir-6864-5p ; hsa-mir-3941 ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-1228-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-511-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6740-3p ; hsa-mir-7154-5p ; hsa-mir-4469 ; hsa-mir-8060
Nearest miRNA
hsa-mir-124-1/Upstream/17381640; hsa-mir-10400/Downstream/1436873;
Nearest TSS
ENST00000518652/Upstream/45242; ENST00000481569/Downstream/3409;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/104147, chr8-CpG: 105/Downstream/2838
Upstream sequence
CTTGAGTTTGCAGAAATATTGGAAGGGAAAGAACAATAAGGAGGAAATTATTACCATGACAGAGAGGATAAGGGGAATCTGAAGGAGGAAGGTCTCCAGG
Downstream sequence
GAGGCAGGAAAAAAGGGTTCTGGATCATGAGTATCCAAATCAGGCCTAGACAGAAGTGCAGACACTTCTTCTTCAGTGGGCAGGGGTGGAAGAAGGAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate