Basic Information
VIS ID
TVIS44011524
Fusion event
HTLV-1-IMPA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
82569475/81657240 (Hg38)
End
82569475/81657240 (Hg38)
Orient
+
Location type
UTR3
Target gene
IMPA1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-132-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-365a-3p ; hsa-mir-27a-3p ; hsa-mir-6504-3p ; hsa-mir-548aw ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4252 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-6889-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-12123/Upstream/1415767; hsa-mir-10400/Downstream/9548245;
Nearest TSS
ENST00000518652/Upstream/125862; ENST00000297265/Downstream/17181;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/26000, chr8-CpG: 41/Downstream/28792
Upstream sequence
ATATGCAACTGCATTTAGAATAAACAGATGGAAAAGCTATTGTAGAAAAAAATATAGGTTTTTAGAAAAGTTGGAAAGATTACAGGCAAAAAATAAGAAC
Downstream sequence
ATATATTAAATTACATTTGCAAGTTTCAAATATTTGTAACTCAACACAAAAACCTCTAAAAGTATGTTgggtgcaatggctcacatctgtaatcccagca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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