Basic Information
VIS ID
TVIS44011528
Fusion event
HTLV-1-TMEM67 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
94816838/93804610 (Hg38)
End
94816838/93804610 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
TMEM67
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-1227-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-3926 ; hsa-mir-4252 ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-20a-3p ; hsa-mir-1273g-3p ; hsa-mir-8063 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-6878-3p ; hsa-mir-4512 ; hsa-mir-4775 ; hsa-mir-223-3p ; hsa-mir-4697-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-1304-3p ; hsa-mir-16-1-3p ; hsa-mir-6760-3p ; hsa-mir-1208 ; hsa-mir-32-3p ; hsa-mir-7850-5p ; hsa-mir-6515-5p ; hsa-mir-7977 ; hsa-mir-4443 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6730-3p ; hsa-mir-383-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-5007-3p ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-103a-2-5p ; hsa-mir-8069 ; hsa-mir-758-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-12123/Upstream/774771; hsa-mir-10400/Downstream/111412;
Nearest TSS
ENST00000518652/Upstream/9794; ENST00000518896/Downstream/6672;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/49624, chr8-CpG: 136/Downstream/111680
Upstream sequence
gagtttccctatgttgcccagacttgtttcTCCCTTTCTTGGAAAATATCTTCAATCTCTTTTTCAAACATTTAAAAAAAAAAAAAACACAAACCTTATT
Downstream sequence
ATCCTTCATTACTTTATTATCCTCTTTATATATTTCCCAAGAATACAATCTTCATTATTTTGGGAAAAAGAAAGCAATTTTAAGGAAAACTTAATTTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate