VISDB - VIS Detail

Basic Information

VIS ID

TVIS44011533

Fusion event

HTLV-1-TRPS1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr8

Cytoband

q23.3

Reference genome

GRCh37/hg19

Start

116463983/115451755 (Hg38)

End

116463983/115451755 (Hg38)

Orient

Location type

Intronic

Target gene

TRPS1

miRNAs that regulate target gene

hsa-mir-372-3p ; hsa-mir-302d-3p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-99b-5p ; hsa-mir-548c-3p ; hsa-mir-200c-3p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-590-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-323a-3p ; hsa-mir-125a-5p ; hsa-mir-150-5p ; hsa-mir-155-5p ; hsa-mir-214-3p ; hsa-mir-218-5p ; hsa-mir-526b-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-1277-5p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-513a-3p ; hsa-mir-941 ; hsa-mir-3667-5p ; hsa-mir-510-3p ; hsa-mir-2054 ; hsa-mir-889-3p ; hsa-mir-593-5p ; hsa-mir-767-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-4699-3p ; hsa-mir-380-3p ; hsa-mir-28-3p ; hsa-mir-6512-5p ; hsa-mir-203a-3p ; hsa-mir-4668-5p ; hsa-mir-4424 ; hsa-mir-27b-5p ; hsa-mir-8066 ; hsa-mir-548n ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-6739-3p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-375 ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-371a-5p ; hsa-mir-371b-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-616-5p ; hsa-mir-6822-3p ; hsa-mir-760 ; hsa-mir-8057

Nearest miRNA

hsa-mir-12123/Upstream/2808172; hsa-mir-10400/Downstream/1422973;

Nearest TSS

ENST00000518652/Upstream/1169619; ENST00000415088/Downstream/40466;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/2018899, chr8-CpG: 33/Downstream/196450

Upstream sequence

TTATGCTGGTGCTTCAATGACGTTCTGTTCAACCCTGGCACAAGATACCCTTTGCAGAAAAATCAGCCTGGTGGGGTATCGTTCGTTTGTTTTCACCTCA

Downstream sequence

CCATTTTGTTATGATGTATAGGCAATGAGCCTCATGTGGCCTTCCTAATCTGAAAATGAGCCAAGAGAAAGAACGTGCTCAGAAGTGTTGAAAGAAAGGC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.