Basic Information
VIS ID
TVIS44011535
Fusion event
HTLV-1-EXT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
118979852/117967613 (Hg38)
End
118979852/117967613 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
EXT1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6077 ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-646 ; hsa-mir-2278 ; hsa-mir-510-3p ; hsa-mir-513b-5p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6124 ; hsa-mir-4668-5p ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-5003-5p ; hsa-mir-654-3p ; hsa-mir-6074 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-203a-3p ; hsa-mir-186-5p ; hsa-mir-3133
Nearest miRNA
hsa-mir-12123/Upstream/1092813; hsa-mir-10400/Downstream/1357558;
Nearest TSS
ENST00000518652/Upstream/437249; ENST00000366457/Downstream/142801;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/446541, chr8-CpG: 76/Downstream/144122
Nearest cancer related gene
EXT1(TSG, No orient, 0)
Upstream sequence
TTATAAATGGAAACATAAAATATGGTTTGAACTAAACAAAACAAACTTTGGGGGAAAAAGGAAAACCAAACCCAGGAACTAAGCCTGCTTTATTAATTCC
Downstream sequence
AAAGGCCCAAAGTCAAATGAGATGAGCACTTGGATAACAAGGGCAATCATCCCCTTTAATAATGGAACTATGGCTATTATTACGGTTGTTGCTAATAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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