Basic Information
VIS ID
TVIS44011567
Fusion event
HTLV-1-CARNMT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77635618/75020702 (Hg38)
End
77635618/75020702 (Hg38)
Orient
+
Location type
Intronic
Target gene
CARNMT1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-196a-5p ; hsa-let-7d-5p ; hsa-mir-149-5p ; hsa-mir-8081 ; hsa-mir-1304-5p ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-506-3p ; hsa-mir-873-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-610 ; hsa-mir-665 ; hsa-mir-4433a-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-127-5p ; hsa-mir-3140-3p ; hsa-mir-2115-5p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-8060 ; hsa-mir-208b-5p ; hsa-mir-208a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/4210618; hsa-let-7a-1/Downstream/8949046;
Nearest TSS
ENST00000422679/Upstream/67734; ENST00000346234/Downstream/6397;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/67580, chr9-CpG: 104/Downstream/7086
Upstream sequence
TCTTTGTCATTTGGTTTCTTAAATCTTCATTCATCCAAACAATTTTCTTATTTTTACCCTCTGCCAAATTATTCCAACTGCCAAACAGTAATGAACTTCA
Downstream sequence
GAAGAAGCTCCTGACAAACAACCAAAAACCTGGCTGGTCGCGTTTTTACAAGCTTGTGTTTGGTGGCTTGGTGTGGGGGGCCCTTAGGGATAAGGTGAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate