Basic Information
VIS ID
TVIS44011573
Fusion event
HTLV-1-LOC105376244 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
120562188/117799910 (Hg38)
End
120562188/117799910 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
LOC105376244
Nearest miRNA
hsa-let-7a-1/Upstream/3590381; hsa-mir-12126/Downstream/2445069;
Nearest TSS
ENST00000422679/Upstream/16462; ENST00000456032/Downstream/97346;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/54546, chr9-CpG: 97/Downstream/1568898
Nearby gene
TLR4(+82419) ;
Upstream sequence
CTCACAGCCCTCTAAGGATGAAGTTAGTAACAAATAACCCCTTGGAAGAGTTTCAGACCTATATTATACCTTggactaacttttctttttaggacacttg
Downstream sequence
agccttgtaggttttgaacaaatcagaagaagagagaagtctcaaaagttagaattcatgttattaaggcaactgggaactagtgtaaatcattaaacca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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