Basic Information
VIS ID
TVIS44011581
Fusion event
HTLV-1-REPS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
17123862/17105739 (Hg38)
End
17123862/17105739 (Hg38)
Orient
+
Location type
Intronic
Target gene
REPS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4727-5p ; hsa-mir-6780a-3p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-519d-5p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-3656 ; hsa-mir-383-3p ; hsa-mir-675-5p
Nearest miRNA
hsa-mir-3690-1/Upstream/478654; hsa-let-7f-2/Downstream/320142;
Nearest TSS
ENST00000429181/Upstream/31226; ENST00000470686/Downstream/29955;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/158390, chrX-CpG: 212/Downstream/269297
Upstream sequence
GAGCCCAGTACTCAGCCTATCAGCTGCCTAACTATGGAGATTTCAGATTTCAGGAACAGGTGTGTAAGAAATGGAGGCAGAAGATCCACATTCCATTTCT
Downstream sequence
CTCCCCTATTCCCTCCTTTCACCCACTGTAAGTGGGACACACATATTCAGATATATGAAGTCCTGGGCAATAAACACATGGTTATATTTAGTTTTTGTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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