Basic Information
VIS ID
TVIS44011587
Fusion event
HTLV-1-USP9X integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.4
Reference genome
GRCh37/hg19
Start
40947967/41088714 (Hg38)
End
40947967/41088714 (Hg38)
Orient
-
Location type
Intronic
Target gene
USP9X
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1180-3p ; hsa-mir-330-3p ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-mir-92a-3p ; hsa-mir-26b-5p ; hsa-mir-640 ; hsa-mir-3160-3p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-3151-3p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-6818-3p ; hsa-mir-548s ; hsa-mir-4684-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-6849-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-1283 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-544b ; hsa-mir-7162-3p
Nearest miRNA
hsa-mir-1587/Upstream/1251101; hsa-let-7f-2/Downstream/4657443;
Nearest TSS
ENST00000429181/Upstream/3079; ENST00000467173/Downstream/78431;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2047, chrX-CpG: 34/Downstream/164851
Upstream sequence
CTAAGTCTTTTGGGCAGTGAAGGTGAGGGGGGTCTTATCCTGAGATTGAGTTAGTTGATTTTTATTCTGAAAGAACGTATTACTTTTTATGGTAGCCTAC
Downstream sequence
ATTATGTTTCCCCTCTTGTAGGTATGTTTTCTGAGTCTTGAATTGTTTTTCTTTTTTTTTTCAAAAAGGGAAAAAACCGGATTTTAGTTGTCATTTGGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate