Basic Information
VIS ID
TVIS44011605
Fusion event
HTLV-1-PCDH19 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99641804/100386806 (Hg38)
End
99641804/100386806 (Hg38)
Orient
-
Location type
Intronic
Target gene
PCDH19
miRNAs that regulate target gene
hsa-mir-624-3p ; hsa-mir-335-3p ; hsa-mir-6885-3p ; hsa-mir-5096 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-198 ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-129-5p ; hsa-mir-3140-3p ; hsa-mir-548m
Nearest miRNA
hsa-let-7f-2/Upstream/5323580; hsa-mir-105-1/Downstream/6253008;
Nearest TSS
ENST00000429181/Upstream/90506; ENST00000485971/Downstream/19709;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/447206, chrX-CpG: 378/Downstream/19849
Upstream sequence
TAAGGAACTGAACTACAAAGGAGGCTGGGGTGGGAGGTCCCTCAATTTTTAGACCCTTCTTTCATGCCCACTCACATGAAAAAATCAAGATATTTCTTTC
Downstream sequence
TATCAAATGCTCCATGCTGTAACATGAAAACCTTATAATTCAAATTTAAACCCATCTAGTTAAATGGTTGCACATATAAGAAATATATAGTCCTGCTGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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