Basic Information
VIS ID
TVIS44011619
Fusion event
HTLV-1-MAMLD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
149634170/150465904 (Hg38)
End
149634170/150465904 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
MAMLD1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-513a-5p ; hsa-mir-4451 ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-6873-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-1323 ; hsa-mir-140-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-4724-5p ; hsa-mir-497-3p ; hsa-mir-499a-3p ; hsa-mir-499b-3p ; hsa-mir-548o-3p ; hsa-mir-7-1-3p ; hsa-mir-7-2-3p
Nearest miRNA
hsa-let-7f-2/Upstream/237821; hsa-mir-105-1/Downstream/702318;
Nearest TSS
ENST00000429181/Upstream/20450; ENST00000464149/Downstream/43421;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/100081, chrX-CpG: 37/Downstream/81797
Upstream sequence
ACCCTGCTGTCATCAAGACCGCAGAGACTGGAGAAAAGCACATGGGTGAAGCAGGGAGATTCATTTAGAAAGGGCTGGGAGCTTGGTTGGGGACCTTCCG
Downstream sequence
CCCCTACCAGGATTCTGGGAGGGGAGGTCATTCCGGAGCAGTGAGCTATCTCCTGCCCTTGATCTAAAATGGTGGCTGTGGGATTTAGTCAGAAACACCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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