Basic Information
VIS ID
TVIS44011624
Fusion event
HTLV-1-TNFSF14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
6668675/6668664 (Hg38)
End
6668675/6668664 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
TNFSF14
miRNAs that regulate target gene
hsa-mir-5698 ; hsa-mir-3689d ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-7641 ; hsa-mir-7977 ; hsa-mir-143-5p ; hsa-mir-3650 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-6499-3p ; hsa-mir-4695-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-4433b-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-3691-5p ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6744-5p ; hsa-mir-4480 ; hsa-mir-4670-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-361-3p ; hsa-mir-1224-3p ; hsa-mir-3691-3p ; hsa-mir-2114-5p ; hsa-mir-3149 ; hsa-mir-4775 ; hsa-mir-411-5p ; hsa-mir-4735-5p ; hsa-mir-590-3p ; hsa-mir-4705 ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6504-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-1227/Upstream/252153; hsa-let-7e/Downstream/68048;
Nearest TSS
ENST00000633603/Upstream/64561; ENST00000596543/Downstream/1453;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8581, chr19-CpG: 39/Downstream/38437
Upstream sequence
gcacggtggcggatgcctgtgatcccagctactgctcaggaggctgagacaagggaatcacttgaacctgggaggtggggttgtagtgagccaagactgc
Downstream sequence
accactacactacagcctgggctatgggagagaaaccttgtctcaaaaaaaaaaaaaTGCAGACAGCGAGATGGCTGGACACATGGACACCACCCTTGGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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