Basic Information
VIS ID
TVIS44011653
Fusion event
HTLV-1-AKR1C1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
5021450/4979258 (Hg38)
End
5021450/4979258 (Hg38)
Orient
+
Location type
Intronic
Target gene
AKR1C1
Nearest miRNA
hsa-mir-5699/Upstream/987999; hsa-mir-107/Downstream/1172938;
Nearest TSS
ENST00000439456/Upstream/13767; ENST00000451575/Downstream/16230;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/152653, chr10-CpG: 54/Downstream/433210
Nearby gene
AKR1C1(+1292) ;
Upstream sequence
AATTACTTATTCTATAAAATTGGAGTAGGCCAtaaactttggagggccctagaccaattttttggattatttttcgtcttctatcattccgctgatctta
Downstream sequence
gatattctctgcattaaatattaaatatcacttctaggctgaaaaatccccctaaaaatatttctagctcagatttttcctccaaattctgcaatagaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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