Basic Information
VIS ID
TVIS44011654
Fusion event
HTLV-1-ZC3H14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
89075097/88608753 (Hg38)
End
89075097/88608753 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZC3H14
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-374b-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-4519 ; hsa-mir-4274
Nearest miRNA
hsa-mir-1260a/Upstream/11342463; hsa-mir-1185-1/Downstream/5339473;
Nearest TSS
ENST00000550708/Upstream/331; ENST00000553718/Downstream/10959;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/45159, chr14-CpG: 136/Downstream/183299
Upstream sequence
ATTTTGGCCACACGCAGTATACACAGATTTTGAGGAGTTGAGGGAAAAGTTAGTTATGGGTAATGAAAACATTTTGGACTTGGGTTAAATTTTTCCTTAC
Downstream sequence
AAGCTGGCTGGCTCAATGTAATGAGCTTTATGAGATGGCTTTTTGGGGCTTCTTTTTTTTGCCGGGGGTAGGTCCTATGGATGGAATCTTCATTTTTAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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