Basic Information
VIS ID
TVIS44011656
Fusion event
HTLV-1-ABR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1112437/1209143 (Hg38)
End
1112437/1209143 (Hg38)
Orient
-
Location type
Intronic
Target gene
ABR
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-93-3p ; hsa-mir-92b-3p ; hsa-mir-18a-5p
Nearest miRNA
hsa-mir-3183/Upstream/186584; hsa-mir-10226/Downstream/504760;
Nearest TSS
ENST00000595228/Upstream/21821; ENST00000391429/Downstream/19861;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/5058, chr17-CpG: 199/Downstream/19310
Nearby gene
ABR(-21821) ;
Upstream sequence
GAACTCTTTCCCTTGGTTCACTGCTCGGCTCAATGCAGGTGCCAATAAAGTTTGCCTTCATGGTGCCTGAATCCCTTTCTTCCGGATGGAGTTCATGGGA
Downstream sequence
GCTTGGAATTGATAGAGTTCATGGGAGCCTGGAACTTACAGTCATAAAATCAGACATACAGTGTTTTACTCTCTGCAGCTGCGTTGAAGTGGGTGGTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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