Basic Information
VIS ID
TVIS44011663
Fusion event
HTLV-1-PGBD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
28257716/28289939 (Hg38)
End
28257716/28289939 (Hg38)
Orient
+
Location type
Intronic
Target gene
PGBD1
miRNAs that regulate target gene
hsa-mir-4733-5p ; hsa-mir-676-5p ; hsa-mir-3146
Nearest miRNA
hsa-mir-3143/Upstream/1142251; hsa-mir-10398/Downstream/2294393;
Nearest TSS
ENST00000381078/Upstream/8367; ENST00000341464/Downstream/36778;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/8148, chr6-CpG: 25/Downstream/93406
Upstream sequence
ttgagacaacgaaaagtcaaaatctagaggaatggaattaaagcatataatttttttctgtgtgtttctgcctttgtttctactcttgtatttgggatct
Downstream sequence
aagataagttgttatctctttaaaataacttattatatctgaaggtcttctttgtaagcctcatgataactacaatgcaaaaacctataataaattcact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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