Basic Information
VIS ID
TVIS44011665
Fusion event
HTLV-1-GOPC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117912401/117591238 (Hg38)
End
117912401/117591238 (Hg38)
Orient
-
Location type
Intronic
Target gene
GOPC
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-103a-3p
Nearest miRNA
hsa-mir-10398/Upstream/10807018; hsa-mir-1202/Downstream/1477809;
Nearest TSS
ENST00000381078/Upstream/17667; ENST00000368494/Downstream/11126;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/42871, chr6-CpG: 55/Downstream/10955
Nearest cancer related gene
GOPC(OG, No orient, 0)
Upstream sequence
accacacccggccCCAAATGTCCAATTTTAAAAAGGGGCCAAATACCAATTCTGTAATCCTTATATAAACCAATCTGATATCTATACCAAAGGAAGTACT
Downstream sequence
CAGCAATGTGGTTTGGGAGCATGGAAGCAAAGAATACAAAAAACAAACAAAAAGCTCCTAGAAACCAAAATAAGTTCACAAAAAGATAATGCTGCCTTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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