Basic Information
VIS ID
TVIS44011666
Fusion event
HTLV-1-ZNF425 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
148822118/149125026 (Hg38)
End
148822118/149125026 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ZNF425
miRNAs that regulate target gene
hsa-mir-4529-3p ; hsa-mir-8058 ; hsa-mir-5009-5p ; hsa-mir-1269a ; hsa-mir-1269b ; hsa-mir-4709-3p ; hsa-mir-6503-3p ; hsa-mir-1306-3p
Nearest miRNA
hsa-mir-10399/Upstream/1746905; hsa-mir-153-2/Downstream/2113395;
Nearest TSS
ENST00000635602/Upstream/11572; ENST00000485111/Downstream/1280;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/20044, chr7-CpG: 97/Downstream/1096
Upstream sequence
GAAAACGATTTTTCCTTGCCTATCCCAAATAATACATTAGCCAATAAACTGTTACCACATTTTCTATAAATTCAATGTACAAAGAAGAGCTACCACAAAC
Downstream sequence
TTTCCCAGAACAGAGAGGAATATTCCAGGAGATTCCCAATCACTTAAAGAGGAGAGAAAAAAAGAAAGCCTGGCTGTAGAAACAAAGCTTGGAGAAATCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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