VISDB - VIS Detail

Basic Information

VIS ID

TVIS44011671

Fusion event

HTLV-1-NHS integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chrX

Cytoband

p22.13

Reference genome

GRCh37/hg19

Start

17616416/17598296 (Hg38)

End

17616416/17598296 (Hg38)

Orient

Location type

Intronic

Target gene

NHS

miRNAs that regulate target gene

hsa-mir-548n ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-590-3p ; hsa-mir-4775 ; hsa-mir-4477a ; hsa-mir-9-3p ; hsa-mir-153-5p ; hsa-mir-4760-3p ; hsa-mir-4503 ; hsa-mir-6792-5p ; hsa-mir-4284 ; hsa-mir-3159 ; hsa-mir-6510-5p ; hsa-mir-4690-5p ; hsa-mir-6165 ; hsa-mir-5197-5p ; hsa-mir-24-3p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-889-5p ; hsa-mir-8076 ; hsa-mir-32-3p ; hsa-mir-651-3p ; hsa-mir-5692a ; hsa-mir-3909 ; hsa-mir-6852-3p ; hsa-mir-520f-5p ; hsa-mir-382-5p ; hsa-mir-495-5p ; hsa-mir-4470 ; hsa-mir-580-5p ; hsa-mir-607 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-1257 ; hsa-mir-3671 ; hsa-mir-580-3p ; hsa-mir-3163 ; hsa-mir-8084 ; hsa-mir-4652-3p ; hsa-mir-578 ; hsa-mir-4743-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-338-5p ; hsa-mir-1277-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-7161-5p ; hsa-mir-548a-5p ; hsa-mir-548u ; hsa-mir-494-3p

Nearest miRNA

hsa-mir-3690-1/Upstream/172342; hsa-let-7f-2/Downstream/2418792;

Nearest TSS

ENST00000429181/Upstream/40909; ENST00000485305/Downstream/36997;

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/220602, chrX-CpG: 84/Downstream/56969

Upstream sequence

TCTTTTGTGGCAGTTCCTGGCAGTCCCAGATGTGGCTCGTTGTCAAGCCTCTGGACCAATGCCCGGAGCCTGTTGGGAGTCCAGACTCCAAGTCAAGAAG

Downstream sequence

AACAGAATTAACTGGCCAGGCGCCAAGATAATATTTTTCCCTCATAAGCAAGAATGCTGCCTAGGAAATAAGTTTAACTCCTTTCTTATTTCCTTAACTC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.