Basic Information
VIS ID
TVIS44011682
Fusion event
HTLV-1-FTCDNL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
200622536/199757813 (Hg38)
End
200622536/199757813 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
FTCDNL1
Nearest miRNA
hsa-mir-10b/Upstream/10624702; hsa-mir-1244-1/Downstream/7025421;
Nearest TSS
ENST00000437798/Upstream/126082; ENST00000319974/Downstream/91157;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/98332, chr2-CpG: 85/Downstream/92852
Nearby gene
FTCDNL1(No orient, 2723)
Upstream sequence
TGGCAGCTGGATGGCTTGTAGTCAGTGTAGTTTTGCAGCTGGTGGTGGTAGCAATTGGCAAAAACTAACTGTCCAGATGGGCATTAAATTTTCTTTAATG
Downstream sequence
TTTATAATATGTCAAAAGAGAATAATCCTATGTCAAAGTGGCTTAGAAGAACTTTTACTCAGGAGCTTACAGAAATTCCTTTTTGACAAAATGGAGGTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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