Basic Information
VIS ID
TVIS44011690
Fusion event
HTLV-1-TRAPPC9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
141228194/140218095 (Hg38)
End
141228194/140218095 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
TRAPPC9
miRNAs that regulate target gene
hsa-mir-30e-5p ; hsa-mir-196a-5p ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-6873-5p ; hsa-mir-583
Nearest miRNA
hsa-mir-1204/Upstream/5413150; hsa-mir-10400/Downstream/514469;
Nearest TSS
ENST00000518652/Upstream/135942; ENST00000518971/Downstream/20398;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/117210, chr8-CpG: 32/Downstream/120646
Upstream sequence
aagagagcaatactctgtctccaaaaaaaaaaaaaaGTCATGGCGAAAGTCTAGAAGGAGTTCAAGTGCTCAGATAAAAGCGTGCCAATAATCTATACAG
Downstream sequence
AAAATCGCAGCTGGTCTCACAGCAAACGGCCAGCAGAGCTGCACGACGCCACCACGACACTCGAACCTCTCCACTACTCCACCAGCATTTAGGAATAAAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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