Basic Information
VIS ID
TVIS44011693
Fusion event
HTLV-1-ARID4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
235400473/235237158 (Hg38)
End
235400473/235237158 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
ARID4B
miRNAs that regulate target gene
hsa-mir-106a-5p ; hsa-mir-19b-3p ; hsa-mir-20b-5p ; hsa-mir-92a-3p ; hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-17-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4325 ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-17-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-302a-3p ; hsa-mir-302e ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-520a-3p ; hsa-mir-520b ; hsa-mir-302c-3p ; hsa-mir-520c-3p ; hsa-mir-302d-3p ; hsa-mir-520d-3p ; hsa-mir-520e ; hsa-mir-302b-3p ; hsa-mir-3691-3p ; hsa-mir-4480
Nearest miRNA
hsa-mir-101-1/Upstream/47042; hsa-mir-1537/Downstream/615842;
Nearest TSS
ENST00000473358/Upstream/2666; ENST00000489692/Downstream/90192;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/75756, chr1-CpG: 157/Downstream/89865
Upstream sequence
gaaggggtttcactatgttggccaggctggtcttgaactcctgacctcaggtgatccgcctgcctcggcctcccaaagtgctgggactgcaggtgtgagc
Downstream sequence
cactgcagctggccTTAAAACATACTTTCAAAAGAAACTCACAAAGACTCCTAGTGCTTTAGAAAGAAAGAAAGAATCGCAAACACTGATGCTTTTTTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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