Basic Information
VIS ID
TVIS44011702
Fusion event
HTLV-1-CHD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
93484507/92941277 (Hg38)
End
93484507/92941277 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHD2
miRNAs that regulate target gene
hsa-mir-450a-5p ; hsa-mir-196b-5p ; hsa-mir-378a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10393/Upstream/36802; hsa-mir-1302-10/Downstream/3391984;
Nearest TSS
ENST00000557528/Upstream/1621; ENST00000625243/Downstream/1663;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/36684, chr15-CpG: 34/Downstream/103595
Upstream sequence
aatcgatacggtcaccatgttggccaggctggtttctaactcctgacctcgtgattcacctgtgtcagcctcccaaagtgctgggattacaggtgtgagc
Downstream sequence
ctccgcgcctagccAATATGTTTCTTTTTTTAAACCAGGAAGTATTTGTGTTGAAGCTTCCAGCAGTCTGGGAATACTTAAATTTCATATTCTTATTACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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