Basic Information
VIS ID
TVIS44011707
Fusion event
HTLV-1-ME2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
48457748/50931378 (Hg38)
End
48457748/50931378 (Hg38)
Orient
-
Location type
Intronic
Target gene
ME2
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-1228-3p ; hsa-mir-1273g-3p ; hsa-mir-194-5p ; hsa-mir-4490 ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-766-3p ; hsa-mir-7703
Nearest miRNA
hsa-mir-1-2/Upstream/804815; hsa-mir-122/Downstream/2305723;
Nearest TSS
ENST00000575820/Upstream/15479; ENST00000591925/Downstream/7739;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/51765, chr18-CpG: 62/Downstream/36528
Upstream sequence
GTGGTCATGCCACATGCCTGTGTTATAAACTGCCTACTGCTGGGTATTATAGCATCATTGAAAACCTGTggctatggagttacaaaaaaatctagattaa
Downstream sequence
gatttaactactacagttttgatgtgtgacttttgacaaagtatttgaaaatattaaagccttagttttctgattttttaaaattagtgaaatggagatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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