Basic Information
VIS ID
TVIS44011709
Fusion event
HTLV-1-PPP1R37 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
45637547/45134289 (Hg38)
End
45637547/45134289 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PPP1R37
miRNAs that regulate target gene
hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-345-3p ; hsa-mir-92b-3p ; hsa-mir-670-5p ; hsa-mir-4319 ; hsa-mir-4325 ; hsa-mir-4732-3p ; hsa-mir-6736-3p ; hsa-mir-7106-3p ; hsa-mir-7113-3p ; hsa-mir-7703 ; hsa-mir-4323 ; hsa-mir-4797-5p ; hsa-mir-6796-3p ; hsa-mir-4267 ; hsa-mir-500a-3p ; hsa-mir-580-3p ; hsa-mir-539-5p ; hsa-mir-137
Nearest miRNA
hsa-mir-10395/Upstream/375568; hsa-let-7e/Downstream/302365;
Nearest TSS
ENST00000633603/Upstream/34225; ENST00000545910/Downstream/2688;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/40676, chr19-CpG: 73/Downstream/10410
Upstream sequence
tgtagagactggctttgttggcaaggctggtctcaaactcttggcctaaagcaatcctcctgtcttggcctcacatagtgctgggattgcaggcgtgagc
Downstream sequence
catgtgcccagtcTCCTCTCTAAAGTGGGAGGATACTAATACTCCCGTGATGGAAGTGATCAGGGAATTGAAGCTGTGTTTATTTGCATTGGAAGTGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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