Basic Information
VIS ID
TVIS44011717
Fusion event
HTLV-1-ARHGEF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
56939594/56905566 (Hg38)
End
56939594/56905566 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF3
miRNAs that regulate target gene
hsa-mir-138-5p ; hsa-mir-373-3p ; hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-377-5p ; hsa-mir-485-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-889-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p
Nearest miRNA
hsa-let-7g/Upstream/1052972; hsa-mir-12124/Downstream/3712239;
Nearest TSS
ENST00000440867/Upstream/103599; ENST00000495939/Downstream/10905;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/103384, chr3-CpG: 112/Downstream/173155
Upstream sequence
tatttatttaagtccccattgactgagtatgtatgtagtttccaatcttctgctgcagcaaatatccttctacataaaccagcctacacgcataagagac
Downstream sequence
tctgtagcattaatatccagaaacagaactgttggggtcaagggaatgtgtatttgtaagtttgctaaacattgccaattggcctccataaagcctgctg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate