Basic Information
VIS ID
TVIS44011728
Fusion event
HTLV-1-ZNF484 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
95613644/92851362 (Hg38)
End
95613644/92851362 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF484
miRNAs that regulate target gene
hsa-mir-4711-3p ; hsa-mir-451b
Nearest miRNA
hsa-mir-101-2/Upstream/323304; hsa-let-7a-1/Downstream/743479;
Nearest TSS
ENST00000422679/Upstream/86550; ENST00000494669/Downstream/26646;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/13639, chr9-CpG: 16/Downstream/61901
Upstream sequence
agaaaactgaagcccttgggccaaatccaggcctctatccaaaagctaacaatgtattttacatttttaaatggtcaaaaaattaaaagaagaatactac
Downstream sequence
ttcacgacatatgaaaattatatgaaattcaaatttcagtgtccataaagtttttattggaacacagccacacccatacattgatgtattgtctatagct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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