Basic Information
VIS ID
TVIS44011729
Fusion event
HTLV-1-PTCH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
98274569/95512287 (Hg38)
End
98274569/95512287 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTCH1
miRNAs that regulate target gene
hsa-mir-212-3p ; hsa-mir-424-5p ; hsa-mir-218-5p ; hsa-mir-561-3p ; hsa-mir-548c-3p ; hsa-mir-4530 ; hsa-mir-4691-3p ; hsa-mir-500b-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-449b-3p ; hsa-mir-1249-3p
Nearest miRNA
hsa-let-7a-1/Upstream/426193; hsa-mir-12126/Downstream/1851267;
Nearest TSS
ENST00000422679/Upstream/3626; ENST00000604650/Downstream/1758;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/661, chr9-CpG: 156/Downstream/3559
Nearest cancer related gene
PTCH1(OG, No orient, 0)
Upstream sequence
GTTTGACTTAATTCCTAAACGTTTTGAACATTGATCCCCGGAGCTTTCAGTGCCCTGAGCCCCCTCGCCCGCTGTTTGATGGGTTAACTTTTCAGCATCT
Downstream sequence
CAGACAATGGTCCCGGCCTGTAAATTCTACCCGTGGGTTCCAGGACGCACTCCGGAGCCTCGGCTCTAACGAGCGCTATCTTAATCTCCCCACCCCCCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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