Basic Information
VIS ID
TVIS44011739
Fusion event
HTLV-1-RASGRP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
38822020/38529819 (Hg38)
End
38822020/38529819 (Hg38)
Orient
+
Location type
Intronic
Target gene
RASGRP1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-335-5p ; hsa-mir-125b-5p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-488-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-29a-3p ; hsa-mir-4517 ; hsa-mir-4524b-3p ; hsa-mir-4645-3p ; hsa-mir-5583-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/1556918; hsa-mir-10393/Downstream/3161766;
Nearest TSS
ENST00000557528/Upstream/5749; ENST00000557946/Downstream/30263;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/75235, chr15-CpG: 137/Downstream/34242
Upstream sequence
attcattcaacatttcttgagtaaatgagtGAACTATATCGAATAGGAAACACGTTAACTTTTCACAGATATTTAGAAATTGAGTTTGCTTTCGTCATTA
Downstream sequence
CCTATTTCATTCGTGAAATGTAATATACACATTTATCTTCTTCCTGGTCACAGTTTGCAAAAGAAATTCAAAGTTACAATTTGGTAAATCATTTTTAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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