Basic Information
VIS ID
TVIS44011751
Fusion event
HTLV-1-ZFAND1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
82632960/81720725 (Hg38)
End
82632960/81720725 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZFAND1
miRNAs that regulate target gene
hsa-mir-125a-5p ; hsa-mir-6885-3p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-182-5p ; hsa-mir-4642 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-3622b-5p ; hsa-mir-1251-3p ; hsa-mir-4670-3p ; hsa-mir-9-5p ; hsa-mir-410-3p
Nearest miRNA
hsa-mir-12123/Upstream/1479252; hsa-mir-10400/Downstream/9484760;
Nearest TSS
ENST00000518652/Upstream/5686; ENST00000297265/Downstream/516;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/34276, chr8-CpG: 53/Downstream/13
Upstream sequence
CCCCAACTCCTCCTGACAGCTACGTAACAGATAAGTAAAAAAAAGTATGGGAAAGTAGCTGGCCGTAGGTCGCAGTGGCAAAGCCAAAAGACAACAGTCC
Downstream sequence
CAGACCAAACCTACGCGTCCCCATACCCGCGCTCAGCAGAGTAAGTGTGAGCCACGCGATCCAGCAGTGGGCTTCGTGCACTGCTCGGACACGGCACACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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