Basic Information
VIS ID
TVIS44011760
Fusion event
HTLV-1-KIF26B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
245369285/245205983 (Hg38)
End
245369285/245205983 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
KIF26B
miRNAs that regulate target gene
hsa-mir-4530 ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-634 ; hsa-mir-629-3p ; hsa-mir-3944-3p ; hsa-mir-627-3p ; hsa-mir-6795-3p ; hsa-mir-4279 ; hsa-mir-501-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1859728; hsa-mir-3124/Downstream/1995984;
Nearest TSS
ENST00000473358/Upstream/50998; ENST00000479506/Downstream/28518;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/49038, chr1-CpG: 23/Downstream/129598
Upstream sequence
tgcccacatctggctaatttaaaaaacttttttttaaagagatggggtcttgttatgttgcccagggtggtctggaactcctggcctcaagcaatcctcc
Downstream sequence
cacctcaccctcccaaagtgcaggaattataggagtgagtcactgagcccagccCCCAAGGAGACTTTTCTGATTGCTGGTCTTTGCCATCCTCAGAGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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