Basic Information
VIS ID
TVIS44011767
Fusion event
HTLV-1-DUXB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
75732119/75698221 (Hg38)
End
75732119/75698221 (Hg38)
Orient
-
Location type
Intronic
Target gene
DUXB
Nearest miRNA
hsa-mir-1225/Upstream/5667799; hsa-mir-11401/Downstream/1170715;
Nearest TSS
ENST00000527434/Upstream/21212; ENST00000463177/Downstream/3238;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/49540, chr16-CpG: 18/Downstream/536858
Nearby gene
TERF2IP(+40778) ;
Upstream sequence
TGGAAACAAGTGAAAAAAGTATAAACACTATGGCAGAGGTAACCTCCAGCTACGTCATTTCCTGAACTTGTCATTTTCACCATGATTCCAAGTGGGACTG
Downstream sequence
GTACCTCTCTCAAAGCCAATTACCAGTATTCCCATAGAATGTACTTTTGTTACTGGGACTTGAGTAATCCTTGCCTCTCACATCCAGTATAGATACATGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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