Basic Information
VIS ID
TVIS44011770
Fusion event
HTLV-1-LOC105376809 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
18334977/18008483 (Hg38)
End
18334977/18008483 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC105376809
Nearest miRNA
hsa-mir-12136/Upstream/730508; hsa-mir-101-1/Downstream/874719;
Nearest TSS
ENST00000473358/Upstream/185501; ENST00000641892/Downstream/7229;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/182136, chr1-CpG: 70/Downstream/99128
Upstream sequence
CTCTTTTCTCTGAGCCTCAGTTAAATAACTGCAGCAGGGGAACATGGACCATGTCAGGCATTTTCAAACCATTTTTTAAAAACCACGGAGGACAGGAAGC
Downstream sequence
CCGTGGACCTTTTCCTTTGGATAAAACCTTAGATGGGTCTCTGATATTACACCAGGTAAGAGTGCTCCCCACTCACCTCCTCTCTCACTTCCACGATCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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