Basic Information
VIS ID
TVIS44011774
Fusion event
HTLV-1-MOB3C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p33
Reference genome
GRCh37/hg19
Start
47082490/46616818 (Hg38)
End
47082490/46616818 (Hg38)
Orient
-
Location type
UTR5
Target gene
MOB3C
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-16-5p ; hsa-mir-377-3p ; hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-6889-3p ; hsa-mir-4707-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-12136/Upstream/2071266; hsa-mir-101-1/Downstream/4443019;
Nearest TSS
ENST00000473358/Upstream/353; ENST00000564071/Downstream/25;
Nearest CpG islands
chr1-CpG: 48/Target, None/Upstream, None/Downstream
Upstream sequence
TTCTGGCCGTGGGGTCACATTCCCAGCCACAGGATCGCCTTTCTCCTGCAGGTCCCGCAGTGCCTGTTCTCTCTCCTGTCAGCCTGTCCGTCTGCCTGTC
Downstream sequence
CTGCCGGCCGCGGCTGCCCTCCTGCCCCGGGCGACGCCAGCTccgccccggccccgccacgccgcggccacggggcggggaggggcggAGAAAGGGGACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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