Basic Information
VIS ID
TVIS44011788
Fusion event
HTLV-1-VCL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
75768658/74008900 (Hg38)
End
75768658/74008900 (Hg38)
Orient
-
Location type
Intronic
Target gene
VCL
miRNAs that regulate target gene
hsa-mir-661 ; hsa-mir-559 ; hsa-mir-34a-5p ; hsa-mir-320b ; hsa-mir-130b-5p ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-222-3p ; hsa-mir-196a-5p ; hsa-mir-16-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-8065 ; hsa-mir-656-5p ; hsa-mir-6799-5p ; hsa-mir-6722-3p ; hsa-mir-6836-5p ; hsa-mir-1909-3p ; hsa-mir-6132 ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-6504-3p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-4700-3p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1265/Upstream/1287800; hsa-mir-107/Downstream/1543558;
Nearest TSS
ENST00000439456/Upstream/10784; ENST00000461383/Downstream/34191;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/10431, chr10-CpG: 50/Downstream/142178
Upstream sequence
AGATGTTTCTTTCTAGAATATGCTGTTTGGTCAGAATTCTTGATGAGGAAGGTCCATTCAGTCAGTTCTTGTTGCTCTCAGGCAGGTCAACCCTTAAACC
Downstream sequence
TTTCCATACAGATAGGACTAGAATAAAAAACAAACTTCTGCCTTGGCATTTTTAAGCTTCAACAACTTTCAGTGCTATATAATGTAAATCCTTAAGAGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate