Basic Information
VIS ID
TVIS44011800
Fusion event
HTLV-1-MYO7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76876561/77165515 (Hg38)
End
76876561/77165515 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYO7A
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10392/Upstream/1830329; hsa-let-7a-2/Downstream/2236507;
Nearest TSS
ENST00000527297/Upstream/37213; ENST00000409893/Downstream/9241;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/17564, chr11-CpG: 18/Downstream/14222
Upstream sequence
CTAGGCTCCTGGGGATCCTGGGTTCTGGGTGCAGAGAATCTCCTTTGCACCAGCGTcctgggttcaagtcttaactctgcccatggcttactgtgtgaca
Downstream sequence
ttagacaactcacttagcttctctgaacatcagttttctccctttgggggcagaggaggtaatccctacctgtcccacatagaaggagctgtgaggGGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate