Basic Information
VIS ID
TVIS44011802
Fusion event
HTLV-1-LOC105369463 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103493682/103622954 (Hg38)
End
103493682/103622954 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105369463
Nearest miRNA
hsa-mir-10392/Upstream/2103049; hsa-let-7a-2/Downstream/226952;
Nearest TSS
ENST00000527297/Upstream/154565; ENST00000527804/Downstream/272317;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/530634, chr11-CpG: 43/Downstream/413723
Nearby gene
DYNC2H1(+143091) ;
Upstream sequence
TTTCGTGGTGTCTTGGAAGGTAGAAGGCTTTCATTAAGGGTTCATGTAACAAGTTTATTCTCCAGTCTTCATCAGAGAACTTCTCAGCAGCTACTAATGC
Downstream sequence
TTCAGCACTTATGACTAGGTTCTCCTGAATGGAGAAGGTTGAGGTGGGCACAGGCGGAAGCAGAATCTTCATCATTGTCCCCCTTACTTTGGTATCATCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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