Basic Information
VIS ID
TVIS44011810
Fusion event
HTLV-1-NBEA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
35537734/34963597 (Hg38)
End
35537734/34963597 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13A
Target gene
NBEA
miRNAs that regulate target gene
hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-935 ; hsa-mir-18a-5p ; hsa-mir-377-3p ; hsa-mir-485-3p ; hsa-mir-127-3p ; hsa-mir-409-5p
Nearest miRNA
hsa-mir-2276/Upstream/10801093; hsa-mir-1267/Downstream/4700437;
Nearest TSS
ENST00000623511/Upstream/20937; ENST00000497540/Downstream/106355;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/20307, chr13-CpG: 54/Downstream/507110
Upstream sequence
tttttggggggatacagtgcagcccataacaGCTGGTCTTAACTAAGCGAAAATAAGGGTAAAATGAGTGATAGTGATAAAAATGTAAGGTCTTTTATTA
Downstream sequence
GTAATGCTTTACTTAAATTCCTGTAAAAATGACAGTTTTCTATTTGTAAACCCATTGCTTTTTTACTTTGAATTATTTCATCCTTTTCCATGCTTCTACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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