VISDB - VIS Detail

Basic Information

VIS ID

TVIS44011812

Fusion event

HTLV-1-KBTBD6 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr13

Cytoband

q14.11

Reference genome

GRCh37/hg19

Start

41701768/41127632 (Hg38)

End

41701768/41127632 (Hg38)

Orient

Location type

UTR3

Target gene

KBTBD6

miRNAs that regulate target gene

hsa-mir-30b-5p ; hsa-mir-34a-5p ; hsa-mir-21-5p ; hsa-mir-10b-5p ; hsa-mir-636 ; hsa-mir-3662 ; hsa-mir-6807-5p ; hsa-mir-505-3p ; hsa-mir-500b-3p ; hsa-mir-7108-5p ; hsa-mir-4474-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30a-5p ; hsa-mir-548au-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-545-5p ; hsa-mir-4495 ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6794-3p ; hsa-mir-4294 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-1304-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4639-3p ; hsa-mir-3664-5p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-4701-5p ; hsa-mir-588 ; hsa-mir-548s ; hsa-mir-7158-3p ; hsa-mir-203b-3p ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4635 ; hsa-mir-3663-5p ; hsa-mir-4477a ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-3529-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p

Nearest miRNA

hsa-mir-2276/Upstream/26532; hsa-mir-1267/Downstream/440654;

Nearest TSS

ENST00000623511/Upstream/66192; ENST00000620300/Downstream/5114;

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/65648, chr13-CpG: 77/Downstream/4434

Upstream sequence

GTGGAATCACTGAAGTAAAAAGTCAGGAAGCATAAGTTCTGGTACCAGTTTTATTTATAATTAACCACATACAAATCACTTTTCTACAAAATAATGGTTA

Downstream sequence

ACATCTATTCCTTAATTCACAGAAATATCACAAAACCAAAATCCTTCCCACGATATATTACTATTTAGTCTAAGCTTTAATTCAAAGGTTGAGAATGACG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.