Basic Information
VIS ID
TVIS44011830
Fusion event
HTLV-1-IGDCC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
65712718/65420380 (Hg38)
End
65712718/65420380 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
IGDCC4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-196a-5p ; hsa-mir-192-5p ; hsa-let-7d-5p ; hsa-mir-423-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-570-3p ; hsa-mir-6859-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-651-3p ; hsa-mir-6748-5p ; hsa-mir-513a-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-7109-3p ; hsa-mir-1303 ; hsa-mir-3678-3p ; hsa-mir-2467-3p ; hsa-mir-3166 ; hsa-mir-202-3p ; hsa-mir-6770-5p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-let-7g-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7f-5p ; hsa-let-7a-5p ; hsa-let-7c-5p ; hsa-let-7e-5p ; hsa-let-7b-5p ; hsa-mir-196b-5p ; hsa-mir-1273e ; hsa-mir-1288-5p
Nearest miRNA
hsa-mir-10393/Upstream/657865; hsa-mir-11181/Downstream/298866;
Nearest TSS
ENST00000557528/Upstream/9295; ENST00000566239/Downstream/2692;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/23356, chr15-CpG: 98/Downstream/2024
Upstream sequence
attcaatctatcctcaagttctactgattctatttcctgaaaatctctggaatgcagccactccagcccaaccccaactgccactatgctagctgccacc
Downstream sequence
atcctctcttctggattgctacaacagcctcgaaggagctggagcttcctgcctccagccccacccaatccatcctccacactggctggaatgaGATGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate