Basic Information
VIS ID
TVIS44011839
Fusion event
HTLV-1-NOG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
54672470/56595109 (Hg38)
End
54672470/56595109 (Hg38)
Orient
+
Location type
UTR3
Target gene
NOG
miRNAs that regulate target gene
hsa-mir-200c-3p
Nearest miRNA
hsa-mir-10226/Upstream/5826379; hsa-mir-1250/Downstream/296161;
Nearest TSS
ENST00000595228/Upstream/1410; ENST00000572810/Downstream/200183;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/123, chr17-CpG: 34/Downstream/1463
Upstream sequence
CTAGCGAGGGTTTTCAATGAACttttttttttttttttttttttttttCTGGGCTACAGAGACCTAGCTTTCTGGTTCCTGTAATGCACTGTTTAACTGT
Downstream sequence
GTAGGAATGTATATGTGTGTGTATATACGGTCCCAGTTTTAATTTACTTATTAAAAGGTCAGTATTATACGTTAAAAGTTACCGGCTTCTACTGTATTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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