Basic Information
VIS ID
TVIS44011845
Fusion event
HTLV-1-CPLX4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56969286/59302054 (Hg38)
End
56969286/59302054 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
CPLX4
Nearest miRNA
hsa-mir-1-2/Upstream/850896; hsa-mir-5011/Downstream/7779530;
Nearest TSS
ENST00000575820/Upstream/27968; ENST00000591331/Downstream/16490;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/27746, chr18-CpG: 35/Downstream/6556
Upstream sequence
TGGTTATGAATATTTTAGAGGAAAGAGGGCAGCTCAGTGTCAAGATCCCTGCTGAAAGGATCCCTGGGATAAAGAAGGCATGGACAGTGAAAGAGACGGT
Downstream sequence
GGGAGAGTATCGGCCCTTAAGAGAAAGATCCGGGACACAGCAAGCAATTAAGAAGCATAAATGGGATTTATACAGTGGACACAGCAGCCTTGTTTCCTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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